The Producer Price Index for finished goods increased by a seasonally adjusted 0.5% for May, according to a Labor Department report (link opens in PDF) released today.
After falling 0.7% in April, these newest numbers put index growth back in the black. Analysts had expected an increase, but their 0.2% estimate proved too conservative.
Source: bls.gov.�
A deeper dive into the data reveals the extent to which volatile energy and food prices affected May's report. Food prices shot up a seasonally adjusted 0.6%, while energy prices jumped 1.3% after dropping 2.5% in April. Excluding these goods, producer price increases clocked in at 0.1%, matching analysts' predictions for that measure.
Moving back along the supply chain, prices for intermediate goods fell 0.1%, or 0.4% excluding food and energy. Industrial chemicals proved the primary culprit of cheaper prices, down 2.3%.
Top 5 Information Technology Companies To Own For 2015: Ameren Corp (AEE)
Ameren Corporation (Ameren), incorporated on August 7, 1995, is a utility holding company. The Company�� principal subsidiaries are Union Electric Company (Ameren Missouri) and Ameren Illinois Company (Ameren Illinois). The Company's segments include Ameren Missouri and Ameren Illinois. Ameren Missouri operates a rate-regulated electric generation, transmission and distribution business, and a rate-regulated natural gas transmission and distribution business in Missouri. Ameren Illinois operates a rate-regulated electric and natural gas transmission and distribution business in Illinois. AER consists of non-rate-regulated operations, including Ameren Energy Generating Company (Genco), AmerenEnergy Resources Generating Company (AERG) and Ameren Energy Marketing Company (Marketing Company). In December 2013, the Company announced that it has completed the divestiture of its merchant generation business, formerly known as Ameren Energy Resources Company, LLC (AER).
Ameren Missouri supplies electric and natural gas service to a 24,000-square-mile area in central and eastern Missouri. This area has an estimated population of 2.8 million and includes the Greater St. Louis area. Ameren Missouri supplies electric service to 1.2 million customers and natural gas service to 127,000 customers. Ameren Illinois supplies electric and natural gas utility service to portions of central and southern Illinois having an estimated population of 3.1 million in an area of 40,000 square miles. Ameren Illinois supplies electric service to 1.2 million customers and natural gas service to 806,000 customers. Ameren has other subsidiaries responsible for activities, such as the provision of shared services. Ameren owns an integrated transmission system that consists of the transmission assets of Ameren Missouri, Ameren Illinois and ATXI.
Ameren operates two balancing authority areas, AMMO (which includes Ameren Missouri), and AMIL (which includes Ameren Illinois, ATXI, AERG, and Genco excluding EEI an! d Genco�� Elgin CT energy center). During the year ended December 31, 2012, the peak demand was 8,868 megawatts in AMMO and 9,720 megawatts in AMIL. The Ameren transmission system directly connects with 15 other balancing authority areas for the exchange of electric energy. Ameren Missouri, Ameren Illinois and ATXI are transmission-owning members of MISO. EEI operates its own balancing authority area and its own transmission facilities in southern Illinois. The EEI transmission system is directly connected to the transmission systems of MISO, the Tennessee Valley Authority, and Louisville Gas and Electric Company. EEI�� energy centers are dispatched separately from those of Ameren Missouri, Genco and AERG.
Ameren�� portfolio of natural gas supply resources includes firm transportation capacity and firm no-notice storage capacity leased from interstate pipelines. Ameren Missouri primarily use the interstate pipeline systems of Panhandle Eastern Pipe Line Company, Trunkline Gas Company, Natural Gas Pipeline Company of America, and Mississippi River Transmission Corporation to transport natural gas to energy centers. Ameren Missouri and Ameren Illinois develop and manage a portfolio supply under term agreements with producers, interstate and intrastate firm transportation capacity, firm storage capacity leased from interstate pipelines, and on-system storage facilities to maintain natural gas deliveries to customers throughout the year and especially during peak demand periods. Ameren Missouri and Ameren Illinois primarily use Panhandle Eastern Pipe Line Company, Trunkline Gas Company, Natural Gas Pipeline Company of America, Mississippi River Transmission Corporation, Northern Border Pipeline Company, and Texas Eastern Transmission Corporation interstate pipeline systems to transport natural gas to their systems.
Advisors' Opinion:- [By Justin Loiseau]
Regulatory resilience
Ameren (NYSE: AEE ) and Dynegy (NYSE: DYN ) aren't letting regulatory snafus get in the way of their plans. The two companies published a statement this week assuring investors that despite the Illinois Pollution Control Board's denial of a variance relief transfer, Dynegy still plans to acquire Ameren Energy Resources.
Top High Tech Stocks To Invest In Right Now: Gleacher & Company Inc.(GLCH)
Gleacher & Company, Inc., an independent investment bank, provides corporate and institutional clients with advice and execution in the areas of advisory services, capital raising and research, sales, and trading. It operates through five segments: Mortgage Backed/Asset Backed & Rates (MBS/ABS & Rates), Corporate Credit, Investment Banking, Equities, and Other. The MBS/ABS & Rates segment provides sales, trading, banking, research, and advisory services on a range of mortgage and asset-backed securities; the United States Treasury and government agency securities; and structured products, such as collateralized loan obligations and collateralized debt obligations, whole loans, and other securities. The Corporate Credit segment offers analysis, sales, and trading on various debt securities comprising bank debt and loans, investment grade debt, high-yield debt, treasuries, convertibles, distressed debt, preferred debt, emerging markets debt, and reorganization equities to co rporate and institutional investor clients. The Investment Banking segment provides financial advisory services in regards to mergers and acquisitions, restructurings, recapitalizations, and capital markets-related matters. It engages in capital raising through underwritings and private placements of equity and debt securities. The Equities segment offers research on customer trades in equity securities in aerospace, defense, industrials, technology, healthcare, and REIT sectors. The Other segment provides early stage growth capital to companies in the information and energy technology sectors. The company was formerly known as Broadpoint Gleacher Securities Group, Inc. Gleacher & Company, Inc. was founded in 1952 and is headquartered in New York, New York.
Advisors' Opinion:- [By Eric Volkman]
Investment bank Gleacher (NASDAQ: GLCH ) has announced that it will exit its mortgage-backed securities and rates business, as well as its credit-products operations. This move, the repercussions of which could potentially affect up to roughly 160 employees, is effective immediately.
- [By Eric Volkman]
The upper ranks of Gleacher (NASDAQ: GLCH ) management have seen a major shake-up. The financial services company has relieved both CEO Thomas Hughes, and COO John Griff, of their jobs. In a tersely worded filing with the Securities and Exchange Commission, it said that the twin terminations were effective immediately. It provided no reason for its actions.
Top High Tech Stocks To Invest In Right Now: Tencent Holdings Ltd (TCEHY)
Tencent Holdings Limited is an investment holding company. The Company and its subsidiaries are principally engaged in the provision of Internet value-added services, mobile and telecommunications value-added services and online advertising services to users in the People�� Republic of China. The Company operates in four segments: Internet value-added services, Mobile and telecommunications value-added services, Online advertising, and Others. As of December 31, 2011, its subsidiaries included Tencent Cyber (Tianjin) Company Limited, Tencent Asset Management Limited, Tencent Technology (Beijing) Company Limited, Tencent Cyber (Shenzhen) Company Limited, Tencent Technology (Shanghai) Company Limited and others. Advisors' Opinion:- [By Victoria Zhang]
Not all social networks are created equally
Renren,�which operates one of the most popular�social networks in the second-largest economy, has lost more than 80% of its market capitalization�since it went public. To put this in perspective, in the same period, competitor Tencent Holdings� (NASDAQOTH: TCEHY ) �experienced massive share appreciation, as its messaging apps�Tencent QQ and WeChat�gained international users, and therefore more advertisers. The company has become the third-largest Internet company in the world, only behind Google and Facebook. - [By Kevin Chen]
In the video below, Fool contributor Kevin Chen details five reasons why SINA may be forever doomed:�
SINA Weibo's daily active users may be exaggerated. Its registered users lag that of competitor Tencent� (NASDAQOTH: TCEHY ) Weibo. Its penetration rate trails Tencent Weibo. Its geographic make-up isn't poised for China's economic growth. Meanwhile, Tencent Weibo is. Renren� (NYSE: RENN ) , the "Facebook of China," and gaming portal�NetEase� (NASDAQ: NTES ) threaten SINA Weibo's viability as a social network.�So before you try to profit from the growing microblogging market in China, watch the video below to learn more about the five things Wall Street overlooks when analyzing SINA.
Top High Tech Stocks To Invest In Right Now: CVB Financial Corp (CVBF)
CVB Financial Corp. (CVB), incorporated on April 27, 1981, is a bank holding company of Citizens Business Bank (the Bank). The Company�� primary operations are related to banking activities, including the acceptance of deposits and the lending and investing of money through the operations of the Bank. The Bank also provides automobile and equipment leasing to customers through its Citizens Financial Services Group and trust and investment-related services to customers through its CitizensTrust Division. The Bank�� customers consist primarily of small to mid-sized businesses and individuals located in San Bernardino County, Riverside County, Orange County, Los Angeles County, Madera County, Fresno County, Tulare County, Kern County and San Joaquin County, California. As of December 31, 2012, the Bank operated 42 Business Financial Centers, five Commercial Banking Centers, and two trust office locations with its headquarters located in the city of Ontario. It operates in two segments: Business Financial and Commercial Banking Centers (Centers) and Treasury.
Lending Activities
The Bank provides lending products, such as commercial, agribusiness, consumer, real estate loans and equipment and vehicle leasing. Commercial products include lines of credit and other working capital financing, accounts receivable lending and letters of credit. Agribusiness products are loans to finance the operating needs of wholesale dairy farm operations, cattle feeders, livestock raisers, and farmers. It provides lease financing for municipal governments. Financing products for consumers include automobile leasing and financing, lines of credit, and home improvement and home equity lines of credit. Real estate loans include mortgage and construction loans. The Bank also offers a range of specialized services designed for the needs of its commercial accounts. These services include cash management systems for monitoring cash flow, a credit card program for merchants, courier pick-up and delivery! , payroll services, remote deposit capture, electronic funds transfers by way of domestic and international wires and automated clearinghouse, and online account access. The Bank makes available investment products to customers, including mutual funds, an array of fixed income vehicles and a program to diversify our customers��funds in federally insured time certificates of deposit of other institutions. It offers a range of financial services and trust services through its CitizensTrust division. These services include fiduciary services, mutual funds, annuities, 401(k) plans and individual investment accounts.
Investment Activities
The Company maintains a portfolio of investment securities to provide interest income and to serve as a source of liquidity for its ongoing operations. The composition of the investment portfolio as of December 31, 2012, consisted of the Government agency, residential mortgage-backed securities, municipal bonds and other securities. Investment securities totaled $2.45 billion at December 31, 2012. Approximately $1.46 billion, or 60%, of the total investment portfolio at December 31, 2012 consisted of securities backed by mortgages.
Sources of Fund
The primary source of funds to support earning assets (loans and investments) is the generation of deposits. CVB offers a range of deposit instruments, which include checking, savings, money market and time certificates of deposit for both business and personal accounts. It also serves as a federal tax depository for its business customers. Total deposits were $4.77 billion at December 31, 2012.. The Company�� deposits include non-interest bearing deposits, such as demand deposits, and interest bearing deposits, such as investment checking, money market, savings and time deposits. At December 31, 2012, borrowed funds totaled $698.2 million. At December 31, 2012, noninterest bearing deposits were 50.71% of total deposits. As of December 31, 2012, its borrowings included $198.9 mill! ion in te! rm federal home loan bank (FHLB) advances, $473.2 million of repurchase agreements, and $26.0 million of other overnight borrowings.
Advisors' Opinion:- [By Rich Duprey]
Citizens Business Bank holding company�CVB Financial (NASDAQ: CVBF ) announced yesterday its second-quarter dividend of $0.10 per share, an 18% increase over the payout it made last quarter of $0.085 per share. This is the first increase in the dividend since 2007.
Top High Tech Stocks To Invest In Right Now: Cubic Corp (CUB)
Cubic Corporation (Cubic), incorporated on December 13, 1984, is an international provider of systems and solutions that address the mass transit and global defense markets. The Company operates in three segments: Cubic Transportation Systems (CTS), Mission Support Services (MSS) and Cubic Defense Systems (CDS). As of the September 30, 2012, the Company�� CTS business accounted for approximately 37%; MSS and CDS accounted for approximately 36% and 27% of its net sales respectively. CTS specialize in the design, development, production, installation, maintenance and operation of automated fare payment and revenue management infrastructure and technologies for transit operators. As part of its turnkey solutions, CTS also provides these customers with a suite of business process outsourcing (BPO) services and expertise, such as card and payment media management, central systems and application support, retail network management, passenger call centers and financial clearing and settlement support. In March 2014, the Company acquired Intific Inc.
Mission Support Services
MSS is a provider of live, virtual and constructive training services to all four branches of the United States military, including the special operations communities, as well as to allied nations. In addition, MSS offers a range of national security solutions to the intelligence community. CDS is a provider of air and ground combat training systems for the United States and allied nations and a key supplier of secure communications solutions, including asset tracking and cyber products and intelligence surveillance and reconnaissance (ISR) data links. Services provided include live, virtual and constructive training, real-world mission rehearsal exercises, professional military education, intelligence support, information technology, information assurance and related cyber support, development of military doctrine, consequence management, infrastructure protection and force protection, as well as support to f! ield operations, force deployment and redeployment and logistics.
Cubic Transportation Systems
CDS focuses on two primary lines of business: training systems and secure communications. CTS is a systems integrator that develops and provides fare collection infrastructure, services and technology for public transport authorities and operators worldwide. The Company offers fare collection devices, software, systems and multiagency, multimodal integration technologies, as well as a suite of operational services. As of September 30, 2012, the Company installed over 90,000 devices and deployed several central systems which in total process approximately 10 billion fare-related transactions per year for approximately seven billion transit passengers.
As of September 30, 2012, the Company had 400 projects in 40 markets on five continents. The Company has implements and, in many cases, operates automated fare payment and collection systems for some of the mass transit systems, such as London, the San Francisco Bay Area and the Los Angeles region. It offers a range of services for transit authorities in transit markets worldwide, including computer hosting services, call center and Web services, payment media issuance and distribution services, retail point of sale network management, payment processing, financial clearing and settlement, software application support and outsourced asset operations and maintenance. The Company provides its services in regions, including London, Sydney, Brisbane, Sweden, Washington district of Columbia, Los Angeles, San Francisco and Atlanta. CTS operate full service operation centers in North America, Europe and Australia. As of September 30, 2012, the Company was designing and building new systems in Chicago, Sydney and Vancouver.
Mission Support Services
MSS provides services within the scope of small-to large-scale military training exercises, including live, virtual and constructive training exercises and suppor! t. Traini! ng services include full life-cycle support from planning through after action reviews as well as the associated support, such as operational, technical and logistical support. In addition, the segment provides a broad range of national security solutions, including subject matter and operational expertise, advanced tactical training and cyber security services, to the intelligence, special operations, law enforcement and homeland security communities. Customers include all branches of the United States military, non-military agencies and allied nations under arrangements with the United States government. MSS is the prime contractor at more than 40 military training and support facilities and supports more than 200,000 exercises and training events per year.
The Company provides training and rehearsals for both small and large scale combat operations, training and preparation of military advisor teams, mobilization and demobilization of forces prior to and following deployment, combat and material development, military staff augmentation, information technology and information assurance, logistics and maintenance support for fielded and deployed systems, support to national security and special operations activities; peacekeeping; consequence management and humanitarian assistance operations worldwide. It plans, prepares, executes and documents realistic and focused mission rehearsal exercises (using both live and computer-based exercises) as final preparation of forces prior to deployment. In addition, it provides consultation and advisory services to the governments and militaries of allied nations.
The Company�� contracts include providing mission support services to three of the United States Army's CTC's: JRTC as prime contractor and the national training center (NTC) and Mission command training program (MCTP) as a principal subcontractor. These services include planning, executing and documenting realistic and stressful exercises and mission rehearsals that increase t! he readin! ess of both active and reserve the United States conventional and special operations forces by placing them in situations as close to actual combat as possible.
MSS is a principal member of the contractor team, to the United States armed services, that supports and helps manage and execute all aspects of the operations of the Joint Coalition Warfare Center (JCWC), including support to worldwide joint exercises and the development and fielding of the Joint National Training Capability (JNTC). Under the Marine Air Ground Task Force (MAGTF) Training Systems Support (MTSS) contract, it provides training and exercise support to the United States Marine Corps forces worldwide, including real-world mission rehearsals. It planned and executed virtually all Marine Corps simulation-based exercises worldwide under the original MAGTF Staff Training Program (MSTP) and its successor, the MTSS, directly preparing Marines for combat operations.
It provides training and professional military education support to the United States Army's Quartermaster Center and School, the Signal School and to the Transportation School. It also provides contractor maintenance and instructional support necessary to operate and maintain a wide variety of flight simulation and training systems and other facilities worldwide, for United States and allied forces under multiple long-term contracts, including direct support to USMC aircrew training systems worldwide. In addition, it provides a range of operational support to the United States Navy for Anti-Submarine Warfare (ASW) and counter-mine operations and training. It provides research, development and technical engineering (RDTE) support to the United States Air Force Research Laboratories (AFRL) for assistance in the identification and application of current, new and emerging technologies to proof-of-principle evaluations of advanced operational concepts. Its services, products and capabilities include development and deployment of curriculum and related cours! eware, co! mputer-based training, knowledge management and distribution, advanced distance learning (e-learning), serious military games for training, and other advanced education programs for United States and allied forces.
Cubic Defense Systems
CDS is focused on two primary lines of business: training systems and secure communications. This segment is primarily a diversified supplier of live and virtual military training systems and secure communications products to the DoD and more than 35 allied nations. The Company designs and manufactures air and ground combat training systems for fighter aircraft, armored vehicles and infantry, as well as weapons effects simulations, laser-based tactical and communication systems. The Company also designs and manufactures secure communications products focused on intelligence, surveillance, asset tracking and search and rescue.
The segment designs, manufactures and fields a range of technologies that are critical to combat readiness, supply chain logistics and national security for the United States and allied nations. Its primary lines of business include air combat training ranges and after action review software, ground combat training systems, including a full range of laser engagement simulation systems, virtual small arms training systems, intelligence, surveillance and reconnaissance (ISR) data links, personnel locator systems, multi-band communication tracking devices and cross domain appliances for cyber security. It also provides ongoing support services for systems it has built for several of its international customers.
Its training systems business designs and manufactures of instrumented training systems and products for militaries of allied nations. It designs and manufactures air and ground combat training systems for fighter aircraft, armored vehicles and infantry, as well as weapons effects simulations, laser-based tactical and communication systems. These systems collect and record simulated weapons eng! agements,! tactical actions and event data to evaluate combat effectiveness and lessons learned and provide a basis to develop after action reviews. It also designs and manufactures secure communications products focused on intelligence, surveillance, asset tracking and search and rescue.
Its training business is organized into air combat, ground combat and virtual training divisions. Ground combat training uses systems analogous to air ranges for ground force training. The systems are generally known as tactical engagement simulation systems or multiple integrated laser engagement system (MILES). It supplies MILES equipment as part of CTC contracts. Its Virtual Training product line provides virtual training systems for various applications, employing actual or realistic weapons and systems together with visual imagery to simulate battlefield environments. Cubic also provides maintenance trainers for combat systems and vehicles, as well as operational trainers for missiles, armored vehicles and naval applications.
Its communications business is a supplier of secure data links, radio frequency amplifiers, direction finding systems, remote video terminals, and search and rescue avionics for the United States military, government agencies, and allied nations. Personnel Locator System (PLS) is standard equipment on United States aircraft with a search and rescue mission. PLS is designed to interface with all modern search and rescue system standards. It also supplies amplifiers and direction finding systems to prime contractors and end users for both domestic and international applications. These include systems used by the Canadian Coast Guard, the United States Navy, the United States Air Force and the French Army.
The Company competes with Lockheed Martin, Northrop Grumman, General Dynamics, Boeing, L3 Communications and SAIC.
Advisors' Opinion:- [By Lee Jackson]
Cubic Corp. (NYSE: CUB) makes the list at J.P. Morgan. It has three major business segments. Cubic Transportation Systems is a leading integrator of payment and information technology and services for intelligent travel solutions. Cubic Defense Systems is a leading provider of realistic combat training systems and secure communications. Mission Support Services is a leading provider of training, operations, maintenance, technical and other support services for the United States and allied nations. Investors are paid a small 0.5% dividend. The J.P. Morgan price target is $57. The Thomson/First Call estimate is $56.20. The stock closed Tuesday at $52.51.
- [By Blake Bos]
In the following video, Fool consumer-goods/industrials analyst Blake Bos breaks down Aviation Week's top aerospace and defense picks by annual revenue. His discussion includes Cubic (NYSE: CUB ) , Rockwell Automation (NYSE: ROK ) , Exelis (NYSE: XLS ) , Boeing (NYSE: BA ) , and Lockheed Martin (NYSE: LMT ) .
- [By Rich Smith]
The Department of Defense awarded San Diego-based Cubic Corporation (NYSE: CUB ) a $19.9 million contract modification Friday, amending a previously awarded firm-fixed-price, foreign-military-sales contract in support of the Israeli military.
Top High Tech Stocks To Invest In Right Now: BioTime Inc (BTX)
BioTime, Inc., incorporated on November 30, 1990, is a biotechnology company focused on the emerging field of regenerative medicine. Its commercial strategy is focused on its line of research products, such as ACTCellerate cell lines and associated ESpan culture media, HyStem hydrogels, human embryonic stem (hES) cell lines, and royalties from Hextend. Its focus is to provide regenerative therapies for age-related degenerative diseases. In January 2011, the Company acquired the assets of Cell Targeting, Inc. (CTI), a biotechnology company focused on methods of painting molecules on the surface of cells, which in turn causes the cells to adhere to particular tissues, such as those afflicted with disease. On March 21, 2011, the Company acquired Glycosan BioSystems, Inc. (Glycosan) through a merger of Glycosan with OrthoCyte Corporation (OrthoCyte). Through the merger, OrthoCyte acquired all of Glycosan�� assets, including Glycosan�� Hystem hydrogel product line. In March 2011, the Company entered into an agreement with XenneX, Inc., pursuant to which it organized LifeMap Sciences, Inc. (LifeMap), a subsidiary formed to advance the development and commercialization of its human embryonic stem (hES) cell data base. In August 2011, four hES cell lines (ESI-035, ESI-049, ESI-051 and ESI-053) developed by its subsidiary ES Cell International (ESI) were approved by the National Institutes of Health (NIH) for inclusion in the NIH Human Embryonic Stem Cell Registry. In May 2012, the Company acquired XenneX, Inc., through a merger of XenneX into LifeMap Sciences. In September 2012, the Company formed a wholly owned subsidiary, BioTime Acquisition Corporation. In October 2013, Geron Corporation announced the closing of the transaction to divest the Company's stem cell assets to Asterias Biotherapeutics, Inc., a subsidiary of BioTime, Inc.
HyStem is a biomaterial, which mimics the human extracellular matrix, which is the network of molecules surrounding cells in organs and tissues which is essent! ial to cellular function. Its HyStem hydrogels may have other applications when combined with the diverse and scalable cell types its scientists have isolated from hES cells. HyStem-Rx is a clinical grade formulation of HyStem-C, a biocompatible, implantable hyaluronan and collagen-based matrix for cell delivery in human clinical applications. Its subsidiary, OncoCyte Corporation, is developing PanC-Dx, a non-invasive blood-based cancer screening test designed to detect the presence of various human cancers, including cancers of the breast, lung, bladder, uterus, stomach, and colon, during routine check -ups. BioTime Asia, Limited (BioTime Asia) sells products for research use and may develop therapies to treat cancer and neurological and orthopedic diseases in Asia. OrthoCyte Corporation (OrthoCyte) is developing therapies to treat orthopedic disorders, diseases and injuries. ReCyte Therapeutics, Inc. (ReCyte Therapeutics) is developing therapies for age-related cardiovascular and blood disorders. Cell Cure Neurosciences Ltd. (Cell Cure Neurosciences), is a biotechnology company focused on developing stem cell-based therapies for retinal and other neurological disorders, including the development of retinal pigment epithelial (RPE) cells for the treatment of age-related macular degeneration. LifeMap Sciences, Inc. (LifeMap) is advancing the development and commercialization of our embryonic stem cell database and plans to make the database available for the marketing of research products and for use by stem cell researchers at pharmaceutical and biotechnology companies and other institutions via paid subscriptions or on a fee per use basis.
The Company�� blood plasma expander product, Hextend, is a physiologically balanced intravenous solution used in the treatment of hypovolemia, a condition caused by low blood volume, often from blood loss during surgery or injury. Hextend maintains circulatory system fluid volume and blood pressure, and keeps vital organs perfused during surgery and t! rauma car! e. Hextend is manufactured and distributed in the United States by Hospira, Inc., and in South Korea by CJ CheilJedang (CJ), under license from it.
Human Embryonic Stem Cell Lines for Research Use
Combined with the Company�� ACTCellerate technology, it derives of a range of markets human embryonic progenitor cells (hEPCs). ESI�� six current good manufacturing practices (cGMP) hES cell lines have been approved by the NIH for inclusion in the Human Embryonic Stem Cell Registry, which renders those cell lines eligible for use in federally funded research. The ESI hES cell lines are available for purchase through www.biotimeinc.com. It also markets hEPCs developed using ACTCellerate technology. Its hEPCs are also available for sale through www.biotimeinc.com. It derived the complete genome sequence of five of the ESI hES cell lines to facilitate the development of products derived from these cell lines. It has made these GMP-grade cell lines, along with certain documentation and complete genomic deoxyribonucleic acid (DNA) sequence information, available for sale.
The Company offers human stem cell products and technology that can be used by researchers at universities and at companies in the bioscience and biopharmaceutical industries. It has developed research and clinical grade hES cell lines, which it markets for both basic research and therapeutic product development. It also markets human embryonic progenitor cell (hEPCs) developed using ACTCellerate technology. These hEPCs are purified lineages of cells, which are intermediate in the developmental process between embryonic stem cells and fully differentiated cells. The ACTCellerate cell lines are also available for purchase through http://www.biotimeinc.com.
Human Embryonic Progenitor Cells
Through the Company�� subsidiary ReCyte Therapeutics, it had a license from Advanced Cell Technology, Inc. (ACT) to use ACTCellerate technology, and the rights to market more than 200 human c! ell types! made using that process. ACTCellerate allows the rapid isolation of hEPCs, which are cells that are intermediate in the developmental process between embryonic stem cells and fully differentiated cells.
Through an agreement with ReCyte Therapeutics, Millipore Corporation became a global distributor of ACTCellerate hEPC lines. In addition to the products, which it is co-marketing with Millipore, it offers 92 other ACTCellerate hEPC lines for purchase at www.biotimeinc.com. Through its subsidiary LifeMap, it provides online biomedical database services to increase awareness of molecular markers and diverse cell types comprising its ACTCellerate hEPC lines. It also focuses to market additional cell types manufactured with its PureStem technology. PureStem cell lines are produced by the exogenous expression of specific transcription factors, which regulate the differentiation of cell types from hES or induced pluripotent stem (iPS) cells. BioTime Asia has an agreement with Shanghai Genext Medical Technology Co., Ltd. to sell ACTCellerate hEPC lines and related ESpan growth media to the medical and biological research communities in China, Taiwan, Hong Kong, and Macau on an exclusive basis. The marketing agreement includes provisions for an initial stocking inventory and annual milestones to maintain exclusivity. The Company�� California Institute of Regenerative Medicine (CIRM)-funded research addresses the need for industrial scale production of purified therapeutic cells.
hES Cells Carrying Genetic Diseases
The Company focuses to add to its product line muscle progenitor cells produced from five hES cell lines carrying genes for Duchenne muscular dystrophy, Emery-Dreifuss muscular dystrophy, spinal muscular atrophy Type I, facioscapulohumeral muscular dystrophy 1A, and Becker muscular dystrophy. It obtained the diseased hES cell lines from Reproductive Genetics Institute (RGI).
ESpan Cell Growth Media
The Company is marketing a range of! cell-gro! wth media products called ESpan. These growth media are optimized for the growth of hEPC types. Cells need to be propagated in liquid media, in both the laboratory setting, where basic research on stem cells is performed, and in the commercial sector. Its ESpan products are marketed through Millipore and Genext.
ESpy Cell Lines
The Company focuses for development of ESpy cell lines. The ability of the ESpy cells to emit light will allow researchers to track the location and distribution of the cells in both in vitro and in vivo studies.
HyStem Hydrogel for Research and HyStem-Rx for Cell Delivery Medical Devices
HyStem is a patented biomaterial that mimics the ECM, the network of molecules surrounding cells in organs and tissues that is essential to cellular function. Its HyStem technology forms the foundation for stem cell delivery products in both the adult and embryonic stem cell marketplace, including products manufactured using its ACTCellerate technology. As an injectable product, HyStem-Rx may address need in cosmetic and reconstructive surgeries and other procedures by transplanting adipose derived cells or other adult stem cells. The transfer of cells in HyStem-Rx localizes the transplanted cells at the intended site and by providing a three-dimensional scaffold upon which cells can rebuild normal tissue. HyStem-Rx may support other emerging cell and tissue transplant therapies, such as those derived from hES and iPS cells, in addition to its potential application in the treatment of a range of conditions such as osteoarthritis, brain tumors, stroke, bone fracture, and wounds.
Advisors' Opinion:- [By Brian Pacampara]
Based on the aggregated intelligence of 180,000-plus investors participating in Motley Fool CAPS, the Fool's free investing community, biotechnology company BioTime (NYSEMKT: BTX ) has received the dreaded one-star ranking.
- [By John Udovich]
Stem cell stocks have not exactly been the best performers lately in part because the controversy over their use has died down over the years while major breakthroughs have been few or far between, but the industry along with small cap stem cell stocks Pluristem Therapeutics Inc (NASDAQ: PSTI), BioTime, Inc (NYSEMKT: BTX) and BioRestorative Therapies (OTCBB: BRTX) are still quietly producing their share of news or minor breakthroughs worth taking note of. Just consider the following stem cell news or news from small cap players in the sector:
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